If visiting museums in Plzeň 3 are on your list, you might want to check out the upcoming exhibitions at Pilsner Urquell Brewery. If you want to see more of the museums in Plzeň 3, you can easily walk to Brewery Museum or West Bohemian Museum.
If you want to see the cathedral in Old Town Plzen, head to St. Bartholomew's Cathedral, in the centre of town. You could also start your cultural experience by heading over to the museums in the area.