If you're planning a bit of sightseeing during your trip, head to Pythagoreion— just one of the monuments in central Pythagorio.
If visiting museums in Pythagorio are on your list, you might want to check out the upcoming exhibitions at Samos Pythagorion Archaeological Museum, located in the heart of town. If you want to see more of the museums in Pythagorio, you can easily walk to Folklore Museum of the Nikolaos Dimitriou Foundation of Samos or Nikolaos Dimitriou Folklore Museum.